Tetrahydrofuran → 7,9-Difluoro-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5H-6-oxa-chrysen-2-ol

関与物質

反応手順

Dissolve 5-{hydroxy-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methyl}-6-(2,3,5-trifluoro-phenyl)-naphthalen-2-ol (4.3 g, 3.0 mmol) in dry THF (85 mL). Add KOtBu (2.4 g, 21.3 mmol) and stir at room temperature for 3 hours. Pour into saturated aqueous ammonium chloride and extract twice with methylene chloride. Dry the organic layer with sodium sulfate, filter and concentrate in vacuo to yield 3.7 g (90%) of the title compound: mass spectrum (ion spray) m/z=488.2 (M+H). The mixture is purified by chiral chromatography (conditions P). The two isomers eluted with retention times of 6.9 and 8.6 minutes.

情報源と証拠