Hydrochloric Acid → 7,9-Difluoro-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5H-6-oxa-chrysen-2-ol hydrochloride salt

Beteiligte Stoffe

Reaktionsschritte

Dissolve 7,9-difluoro-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5H-6-oxa-chrysen-2-ol (1.6 g, 3.3 mmol) in methylene chloride (20 mL). Add 2M HCl in ether (3.3 mL, 6.6 mmol) and concentrate in vacuo. Dissolve the residue in methylene chloride (5 mL) and add dropwise to vigorously stirred ether (30 mL). Filter the precipitate and dry in a 50° C. vacuum oven overnight to obtain 1.5 g (87%) of the title compound. Mass spectrum (ion spray): m/z=488.3 (M+H−HCl).

Herkunft & Nachweise