2-Bromo-1,3,4-trifluorobenzene → [4-(2-Azepan-1-yl-ethoxy)-phenyl]-[6-methoxy-2-(2,3,6-trifluoro-phenyl)-naphthalen-1-yl]-methanone

Beteiligte Stoffe

Reaktionsschritte

Couple trifluoromethanesulfonic acid 1-[4-(2-azepan-1-yl-ethoxy)-benzoyl]-6-methoxynaphthalen-2-yl ester (1.48 g, 2.67 mmol) with 2-bromo-1,3,4-trifluoro-benzene (1.13 g, 5.35 mmol) in a procedure similar to the preparation of [6-hydroxy-2-(2,3,5-trifluoro-phenyl)-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone to give 660 mg (46%) of the title compound: mass spectrum (ion spray): m/z=534.4 (M+H).

Herkunft & Nachweise