反应详情

By the standard demethylation procedure found in the preparation of [2-(2,4-difluoro-phenyl)-6-hydroxy-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone, [4-(2-azepan-1-yl-ethoxy)-phenyl]-[2-(2,4-difluoro-phenyl)-6-methoxy-naphthalen-1-yl]-methanone (1.1 g, 2.1 mmol) is demethylated with BBr3 (1.0 mL, 10.5 mmol) to afford crude product. Purify on silica gel (0% to 5% methanol in methylene chloride) to yield 790 mg (75%) of the title compound: mass spectrum (ion spray) m/z=502.3 (M+H).

1. customto afford crude product
2. customPurify on silica gel (0% to 5% methanol in methylene chloride)