HCID 67401990, compound → HCID 68496213, compound

Participants

Reaction Steps

To a solution of trans-(2,6,6-trimethyl-3-cyclohexen-1-yl)acetonitrile obtained in Example 3b) (3.0 g, purity 98%, 18 mmol) in AcOEt (30 ml) was added 10% Pd—C and the mixture was shaken under H2 (1 atm) at room temperature during 3 days. The catalyst was filtered off through celite and the filtrate was concentrated. Bulb-to-bulb distillation (oven temp 80° C./0.3 mbar) afforded trans-(2,6,6,trimethylcyclohexyl)acetonitrile (2.88 g, purity 99%, yield 98%).

Provenance & Evidence