HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → 2,4-Dibromophenyl 4-(prop-2-ynyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2,4-Dibromophenol | HCID 12005 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Product | 2,4-Dibromophenyl 4-(prop-2-ynyl)piperidine-1-carboxylate | HCID 57838912 | — |
Reaction Steps
2,4-Dibromophenol (7.45 g, 29.6 mmol) was added as a solution in THF and dimethylaniline to a mixture of triphosgene (2.849 g, 9.6 mmol) in THF according to general procedure 3. Yield=6.09 g, 68%. m/z MH+=402.22. HPLC rt=12.49 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222228B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-0f5333db4d764866b907ab7d89c12ca3 |
| Source note | uspto-grants-2012_07 |