HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-[(3S)-piperidin-3-yl]carbamate → tert-butyl N-methyl-N-[(3S)-piperidin-3-yl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-[(3S)-piperidin-3-yl]carbamate | HCID 1514171 | — |
| Reactant | (3R)-N-methylpiperidine-3-carboxamide | HCID 7175805 | — |
| Product | tert-butyl N-methyl-N-[(3S)-piperidin-3-yl]carbamate | HCID 28875358 | — |
Reaction Steps
Prepared from (S)-3-(tert-butoxycarbonylamino)piperdine in the same scale and manner as the (3R) isomer described in Preparative Example 35. Yields were 96% and 93% for the first two steps. Product yield was treated as quantitative for last step and used as reagent in a further reaction (Example 94). LC/MS 1.30 min, [M+1]+ 215.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222243B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-19f160a22f804eac9eec1d7244b12c1e |
| Source note | uspto-grants-2012_07 |