(Isocyanatomethyl)cyclohexane → N-(Cyclohexylmethyl)-2-{3-[4-(3-nitrophenyl)piperazin-1-yl]propanoyl}hydrazine carboxamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A solution of 3-[4-(3-nitrophenyl)piperazino]propanohydrazide D7 (0.55 g, 1.87 mmol) in toluene (30 mL) was heated at 70° C. and cyclohexanemethyl isocyanate (0.28 g, 0.30 mL, 1.96 mmol) was added at once. The slurry was heated at 70° C. until all solid went into solution (15 min) and then cooled to room temperature. The resulting solid was filtered and washed with toluene to afford 0.70 g (95%) N-(cyclohexylmethyl)-2-{3-[4-(3-nitrophenyl)piperazin-1-yl]propanoyl}hydrazine carboxamide D8 as an orange semi-solid.

Herkunft & Nachweise