4-(Cyclohexylmethyl)-5-{2-[4-(3-nitrophenyl)piperazin-1-yl]ethyl}-2,4-dihydro-3H-1,2,4-triazol-3-one → 5-{2-[4-(3-aminophenyl)piperazin-1-yl]ethyl}-4-(cyclohexylmethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Participants

Reaction Steps

To a solution of 4-(cyclohexylmethyl)-5-{2-[4-(3-nitrophenyl)piperazin-1-yl]ethyl}-2,4-dihydro-3H-1,2,4-triazol-3-one D9 (0.30 g, 0.72 mmol) in methanol (20 mL), a catalytic amount of 10% Pd/C was added and the slurry was pressurized to 20-30 bar in an autoclave for 3 days. The catalyst was filtered through a Celite pad and the filtrate was evaporated to afford 0.26 g (93%) 5-{2-[4-(3-aminophenyl)piperazin-1-yl]ethyl}-4-(cyclohexylmethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one D10 as an orange semi-solid.

Provenance & Evidence