反应详情

A slurry of 4-(cyclohexylmethyl)-2-methyl-5-{2-[4-(3-nitrophenyl)piperazino]ethyl}-2,4-dihydro-3H-1,2,4-triazol-3-one (D15; 490 mg, 1.143 mmol) and 10% Pd/C (250 mg) in MeOH (30 mL) was hydrogenated in an autoclave at 30 bar and room temperature for 4 hrs. The reaction mixture was filtered over a pad of Celite and the solvent was removed in vacuo to afford a light-brown film. This was re-dissolved in MeCN (20 mL) and filtered again through a Celite plug. The solvent was evaporated in vacuo to afford 450 mg (99%) of the title compound as a brown solid.

1. filtrationThe reaction mixture was filtered over a pad of Celite
2. customthe solvent was removed in vacuo
3. customto afford a light-brown film
4. filtrationfiltered again through a Celite plug
5. customThe solvent was evaporated in vacuo