反应详情

A suspension of N-(cyclohexylmethyl)-2-{3-[4-(2-methoxyphenyl)piperazino]propanoyl}-1-hydrazinecarboxamide D4 (0.40 g, 0.96 mmol) in 2M NaOH aqueous solution (10 mL) was heated at reflux for 7 hrs. The resulting precipitate was filtered, washed with water and diethyl ether to afford 0.22 g (57%) 4-(cyclohexylmethyl)-5-{2-[4-(2-methoxyphenyl)piperazino]ethyl}-2,4-dihydro-3H-1,2,4-triazol-3-one E17 as a white solid.

1. temperaturewas heated
2. temperatureat reflux for 7 hrs
3. filtrationThe resulting precipitate was filtered
4. washwashed with water and diethyl ether