Trifluoromethanesulfonic anhydride → HCID 59403460, compound

Participants

Reaction Steps

Trifluoromethanesulfonic anhydride (0.253 ml, 1.498 mmol) was added to an ice cooled solution of 1,1-dimethylethyl 8-hydroxy-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (Preparation 30) (0.265 g, 0.999 mmol) in pyridine (4 ml) and stirred for one hour. The reaction mixture was evaporated, dissolved in 40 ml of EtOAc and washed with 20 ml of 2M HCl and 20 ml of saturated sodium bicarbonate then dried (magnesium sulphate) and evaporated to give the title compound (399 mgs) as a yellow gum. MS (ES) C15H18F3NO6S requires 397; found 298 [M+H−100]+.

Provenance & Evidence