HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1514218Generated: November 2, 2026
Methyl 2-[(2-aminoethyl)oxy]-3-(methyloxy)benzoate → 9-methoxy-3,4-dihydro-1,4-benzoxazepin-5(2H)-one
https://huagongshe.com/reaction/1514218
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 2-[(2-aminoethyl)oxy]-3-(methyloxy)benzoate | HCID 59403437 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 9-methoxy-3,4-dihydro-1,4-benzoxazepin-5(2H)-one | HCID 16210758 | 101% |
Reaction Steps
A solution of methyl 2-[(2-aminoethyl)oxy]-3-(methyloxy)benzoate (Preparation 56) (11.9 g, 52.8 mmol) in toluene (200 ml) was stirred and heated at 110° C. for 1 hour then cooled and evaporated to give the title compound (10.3 g) as a sandy coloured solid. MS (ES): C10H11NO3 requires 193; found 194 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08222245B2 |
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| Source dataset | uspto-grants-2012_07 |
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| ORD ID | ord-a9a7a0993cb54828b308306e1bbf2bb5 |
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| Source note | uspto-grants-2012_07 |
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