Hydroxyamine hydrochloride → HCID 178452415, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1,1-dimethylethyl 7-cyano-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (Preparation 74) (2.016 g, 7.35 mmol), hydroxylamine hydrochloride (1.021 g, 14.70 mmol) and sodium bicarbonate (3.09 g, 36.7 mmol) in ethanol (30 ml) was heated at 60° C. overnight. The grey solid was removed by filtration and the filtrate evaporated. The resulting residue was dissolved in EtOAc, washed with water (3×20 ml), dried (MgSO4) and evaporated to give the title compound (1.77 g) as a white solid. MS (ES): C15H21N3O4 requires 307; found 308 [M+H]+.

Provenance & Evidence