Ethyl 4-bromobutyrate → HCID 59403493, compound

Participants

Reaction Conditions

Reaction Steps

7-(5-{3-Chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine (0.105 g, 0.272 mmol) was stirred in acetonitrile (2 ml). DIPEA (0.095 ml, 0.544 mmol) and ethyl 4-bromobutanoate (0.058 ml, 0.408 mmol) were added and the reaction mixture heated at 80° C. under Argon for 5 hours. Additional DIPEA (0.095 ml, 0.544 mmol) and ethyl 4-bromobutanoate (0.058 ml, 0.408 mmol) were added and the reaction mixture heated at 80° C. overnight. Then the reaction mixture was dissolved in EtOAc (20 ml), washed with NaHCO3 (aq) (15 ml×3) and with water (15 ml×3) and the organics dried (MgSO4) and evaporated. The crude was purified by flash chromatography eluting with EtOAc/iso-Hexane 20/30% (Biotage column), and evaporated to give the title compounds as an oil (80 mg). MS (ES): C26H3035ClN3O5 requires 499; found 500 [M+H]+.

Provenance & Evidence