Sodium Hydroxide → HCID 57505923, compound

Participants

Reaction Steps

1-Methylethyl 5-cyano-6-[(1-methylethyl)oxy]-3-pyridinecarboxylate (Preparation 93) (1.28 g, 5.15 mmol) in ethanol (20 ml) was treated with sodium hydroxide (5.15 ml, 10.30 mmol) and the mixture stirred at room temperature to give a homogeneous solution, until LC/MS showed no starting material. The mixture was concentrated to remove ethanol. The residue was diluted with water, then acidfied with 2M HCl to give a thick white precipitate. The solid was filtered off, washed with water and dried overnight in vacuo at 60° C., to give the title compound (1.07 g),

Provenance & Evidence