Hydrochloric Acid → HCID 68467318, compound

Participants

Reaction Steps

1,1-Dimethylethyl 8-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (Preparation 34) (0.171 g, 0.352 mmol) was dissolved in 1,4-dioxane (1 ml) and 4M HCl (4 ml, 16.00 mmol) in dioxane was added. The reaction mixture was left at room temperature for 3 hours. The resulting precipitated solid was filtered off and washed with dioxane and ether to give the title compound (116 mgs) as a white solid hydrochloride salt. δH (400 MHz, MeOD) 1.42 (6H, d), 3.64 (2H, m), 4.34 (2H, m), 4.48 (2H, s), 4.86 (1H, m), 7.31 (1H, d), 7.59 (1H, d), 7.87 (1H, d), 7.94 (1H, dd), 8.11 (1H, dd), 8.21 (1H, dd); MS (ES) C20H2035ClN3O3 requires 385; found 486 [M+H]+.

Provenance & Evidence