Hydrochloric Acid → HCID 68469090, compound

Participants

Reaction Steps

1,1-Dimethylethyl 7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (Preparation 76) (0.410 g, 0.860 mmol) was dissolved in 1,4-dioxane (1 ml). Added HCl (1 ml, 4.00 mmol) in dioxane (4M) and stirred at R.T. for 2 hours. Added ether, filtered and dried in the oven under vacuum at R.T. to give 0.26 g of white solid. 50 mg was purified by MDAP to give the title compound (13 mg) as a cream solid. δH (MeOD, 400 MHz): 1.44 (6H, d), 3.63 (2H, m), 4.33 (2H, m), 4.52 (2H, s), 4.92 (1H, m), 7.30 (1H, d), 7.43 (1H, d), 8.15 (1H, dd), 8.21 (1H, d), 8.38 (1H, dd), 8.45 (1H, d); MS (ES): C21H20N4O3 requires 376; found 377 [M+H]+.

Provenance & Evidence