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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1514302Generated: October 26, 2026

4-[2-(4-Nitro-phenyl)-vinyl]-pyridine → 4-[2-(Pyridin-4-yl)ethyl]aniline

https://huagongshe.com/reaction/1514302

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[2-(4-Nitro-phenyl)-vinyl]-pyridineHCID 307136—
ReactantHCID 178418361HCID 178418361—
CatalystPalladiumHCID 23938—
SolventEthyl AcetateHCID 8857—
Product4-[2-(Pyridin-4-yl)ethyl]anilineHCID 233288100%

Reaction Steps

To the EtOAc solution (30 mL) of 4-[2-(4-nitro-phenyl)-vinyl]-pyridine (160 mg, 0.71 mmol) was added palladium on carbon (0.1 g, 50% wet). The suspension was hydrogenated at 50 psi of hydrogen for 2 hours. The mixture was filtered over a celite pad. The filtrate was concentrate to give 4-(2-pyridin-4-yl-ethyl)-phenylamine as a yellow solid (140 mg, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08222249B2
Source datasetuspto-grants-2012_07
ORD IDord-cf83183b20bf479f9265910aa6ebd255
Source noteuspto-grants-2012_07