反应详情

This compound was prepared in a similar manner as described in example 2, by reaction of 2,6-dichloropurine with 3-fluoroaniline. The reaction mixture was then evaporated on a rotary vacuum evaporator and the residue was partitioned between ethyl acetate and 0.5 M HCl. The organic layer was washed with water, dried with MgSO4, and evaporated to give a yellow solid (3.72 g). The crude product was purified by flash chromatography. Yield: 2.20 g yellow crystalline powder. TLC (chloroform-methanol; 85:15): homogenous. HPLC purity: 98+%

1. customThis compound was prepared in a similar manner
2. customThe reaction mixture was then evaporated on a rotary vacuum evaporator
3. customthe residue was partitioned between ethyl acetate and 0.5 M HCl
4. washThe organic layer was washed with water
5. dry with materialdried with MgSO4
6. customevaporated