1-Propanol → HCID 86643680, compound

Participants

Reaction Steps

2-Bromo-6-(methoxyanilino)purine was prepared in a similar manner to example 5 by the reaction of 2-bromo-6-chloropurine and m-anisidine (molar ratio 1:1) in the presence of triethylamine (2.5 eq.) in n-propanol at 100° C. for 4 hours. After cooling to room temperature the resulting white precipitate was filtered off, washed with cold n-propanol and water and dried in desiccator into constant weight. Yield: 69% (as hydrobromide). Crude product was purified by crystallization from methanol and free base was obtained by treatment of hydrobromide with 10% aqueous ammonia. HPLC purity: 98+%.

Provenance & Evidence