Sodium Bicarbonate → HCID 58026184, compound

Participants

Reaction Conditions

Reaction Steps

Acetic acid N′-(2-bromo-benzyl)-N′-[4-(4-chloro-phenylamino)-6-methyl-pyrimidin-2-yl]-hydrazide (0.4 g, 0.87 mmol) was suspended in aqueous hydrochloric acid (6 M, 50 mL) and heated to 100° C. for 3 days. The reaction mixture was diluted with water (50 mL), basified with solid sodium hydrogencarbonate and extracted with chloroform (3×50 mL). The combined organic phases were washed with brine, dried over sodium sulphate, filtrated and evaporated to give {2-[N-(2-bromo-benzyl)-hydrazino]-6-methyl-pyrimidin-4-yl}-(4-chloro-phenyl)-amine (0.3 g, 82%) as a brown solid.

Provenance & Evidence