反应详情

Using methods described in Example 1, and starting with (S)-(4-(1-chloropyrido[3,4-d]pyridazin-4-yl)-2-methylpiperazin-1-yl)(piperidin-1-yl)methanone 7 (200 mg, 534 μmol), tetrakis(triphenylphosphine)palladium (31 mg, 27 μmol), 4-(hydroxymethyl)phenylboronic acid (122 mg, 800 μmol) and 2 M sodium carbonate (534 μl, 1067 μmol), (S)-(4-(1-(4-(hydroxymethyl)phenyl)pyrido[3,4-d]pyridazin-4-yl)-2-methylpiperazin-1-yl)(piperidin-1-yl)methanone 9 was obtained. MS 446.2 (calc'd) 447.3 (M+H, found).