反应详情

Using methods described in Example 6, and starting with (R)-(4-(5-chloropyrido[2,3-d]pyridazin-8-yl)-3-methylpiperazin-1-yl)(phenyl)methanone 79 (180 mg, 489 μmol), 4-(hydroxymethyl)phenylboronic acid (112 mg, 734 μmol), tetrakis(triphenylphosphine)palladium (28 mg, 24 μmol), and 2 M sodium carbonate (489 μl, 979 μmol) yielded (R)-(4-(5-(4-(hydroxymethyl)phenyl)pyrido[2,3-d]pyridazin-8-yl)-3-methylpiperazin-1-yl)(phenyl)methanone 82 (122 mg, 57% yield) after chromatographic purification. MS 439.2 (calc'd) 440.2 (M+H, found).