HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → (R)-(3-methyl-4-(5-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyridazin-8-yl)piperazin-1-yl)(phenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | (R)-(4-(5-chloropyrido[2,3-d]pyridazin-8-yl)-3-methylpiperazin-1-yl)(phenyl)methanone | HCID 57657595 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | (R)-(3-methyl-4-(5-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyridazin-8-yl)piperazin-1-yl)(phenyl)methanone | HCID 25224710 | — |
Reaction Steps
Using methods described in Example 6, and starting with (R)-(4-(5-chloropyrido[2,3-d]pyridazin-8-yl)-3-methylpiperazin-1-yl)(phenyl)methanone 79 (180 mg, 489 μmol), tetrakis(triphenylphosphine)palladium (283 mg, 245 μmol), 4-trifluoromethylphenylboronic acid (139 mg, 734 μmol), and 2 M sodium carbonate (489 μl, 979 μmol) afforded (R)-(3-methyl-4-(5-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyridazin-8-yl)piperazin-1-yl)(phenyl)methanone 84 after chromatographic purification. MS 477.2 (calc'd) 478.1 (M+H, found).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222251B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-9175f8decb32467eb4b3a03aaa4e76a4 |
| Source note | uspto-grants-2012_07 |