Sodium Carbonate → HCID 25224889, compound

Participants

Reaction Steps

Using methods described in Example 6, and starting with (R)-(4-(8-chloropyrido[3,2-d]pyridazin-5-yl)-3-methylpiperazin-1-yl)(phenyl)methanone (180 mg, 489 μmol), 2 M sodium carbonate (489 μl, 979 μmol), tetrakis(triphenylphosphine)palladium (28 mg, 24 μmol), and 4-trifluoromethylphenylboronic acid (139 mg, 734 μmol) afforded (R)-(3-methyl-4-(8-(4-(trifluoromethyl)phenyl)pyrido[3,2-d]pyridazin-5-yl)piperazin-1-yl)(phenyl)methanone 86 after chromatographic purification. MS 477.2 (calc'd) 478.1 (M+H, found).

Provenance & Evidence