1,4-Dioxane → HCID 178430894, compound

HRID 1514409Notes

Reaction equation

HRID 1514409 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[C:8]([CH3:17])=[CH:7][N:6]=1)(=O)=O.[O:18]1CCOCC1>>[CH3:17][C:8]1[C:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[N:10][C:5](=[O:18])[NH:6][CH:7]=1

Participants

3

Reactant 2

HCID 312751,4-DioxaneHCID 686973182-Methanesulfonyl-5-methyl-4-pyridin-3-yl-pyrimidine

Product 1

HCID 178430894HCID 178430894, compoundYield 97%

Procedure

2-Methanesulfonyl-5-methyl-4-pyridin-3-yl-pyrimidine (1.3 g, 5.22 mmol) was dissolved in dioxane (80 ml) and then 2N NaOHaq (21 ml, 42 mmol) was added dropwise at room temperature. After stirring for 1 hour, the solution was neutralized with 37% HClaq. The residue was purified by flash chromatography with DCM-MeOH—NH4OH (9-1-0.1) to give 951 mg of the title compound as a light brown powder. (97% yield).

Workup

  1. addition2N NaOHaq (21 ml, 42 mmol) was added dropwise at room temperature
  2. customThe residue was purified by flash chromatography with DCM-MeOH—NH4OH (9-1-0.1)

Sources & evidence

ORD record
ord-3c1658f842d34d9a858c62de445ea44c
Source dataset
uspto-grants-2012_07
Patent number
US08222266B2

Reaction notes

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