1,4-Dioxane → HCID 178517422, compound

HRID 1514417Notes

Reaction equation

HRID 1514417 reaction equation
[F:1][C:2]1([F:21])[O:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11]3[CH:16]=[CH:15][N:14]=[C:13](S(C)(=O)=O)[N:12]=3)[C:4]=2[O:3]1.[O:22]1CCOCC1>>[F:1][C:2]1([F:21])[O:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11]3[CH:16]=[CH:15][NH:14][C:13](=[O:22])[N:12]=3)[C:4]=2[O:3]1

Participants

3

Reactant 2

HCID 312751,4-DioxaneHCID 59242795HCID 59242795, compound

Product 1

HCID 178517422HCID 178517422, compound

Procedure

4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2-methanesulfonyl-pyrimidine (364 mg, 1.15 mmol) was dissolved in dioxane (8.5 ml) and then 2N NaOHaq (5.7 ml, 11 mmol) was added. After stirring at room temperature for 1 hour, the solution was acidified with 37% HClaq. The mixture was evaporated and the residue was purified by flash chromatography with DCM-MeOH (9-1) to give 232 mg of the title compound. (quantitative yield).

Workup

  1. addition2N NaOHaq (5.7 ml, 11 mmol) was added
  2. customThe mixture was evaporated
  3. customthe residue was purified by flash chromatography with DCM-MeOH (9-1)

Sources & evidence

ORD record
ord-7bdda5a6a33c44a4b0ba9b164f995c8c
Source dataset
uspto-grants-2012_07
Patent number
US08222266B2

Reaction notes

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