Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[4-(tert-Butyl-dimethyl-silanyloxy)-butyl]-4-(2-fluoro-phenyl)-1H-pyrimidin-2-one → 4-(2-Fluoro-phenyl)-1-(4-hydroxy-butyl)-1H-pyrimidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[4-(tert-Butyl-dimethyl-silanyloxy)-butyl]-4-(2-fluoro-phenyl)-1H-pyrimidin-2-one | HCID 59242790 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-(2-Fluoro-phenyl)-1-(4-hydroxy-butyl)-1H-pyrimidin-2-one | HCID 59242782 | 100.4% |
반응 단계
1-[4-(tert-Butyl-dimethyl-silanyloxy)-butyl]-4-(2-fluoro-phenyl)-1H-pyrimidin-2-one (370 mg, 0.98 mmol) was dissolved in 4N HCl in dioxane (15 ml). The mixture was stirred at room temperature for 15 minutes, then basified with 30% NH4OHaq and finally extracted with DCM. The organic layer was dried (Na2SO4), filtered and evaporated, to give 258 mg of the title compound as a yellow solid (95% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08222266B2 |
| 출처 데이터셋 | uspto-grants-2012_07 |
| ORD ID | ord-1464adfe218b436e985926859976efae |
| 출처 메모 | uspto-grants-2012_07 |