Hydrochloric Acid → 4-(6-methyl-2-pyridinyl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2(1H)-pyrimidinone dihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	1,4-Dioxane	HCID 31275	—
Reactant	4-(6-Methyl-pyridin-2-yl)-1-{4-[(1S,5R)-1-(4-trifluoromethyl-phenyl)-3-aza-bicyclo[3.1.0]hex-3-yl]-butyl}-1H-pyrimidin-2-one	HCID 24752775	—
Product	4-(6-methyl-2-pyridinyl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2(1H)-pyrimidinone dihydrochloride	HCID 68697390	—

Reaction Steps

4-(6-Methyl-pyridin-2-yl)-1-{4-[(1S,5R)-1-(4-trifluoromethyl-phenyl)-3-aza-bicyclo[3.1.0]hex-3-yl]-butyl}-1H-pyrimidin-2-one was treated with 4N HCl in dioxane (2 eq), to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08222266B2
Source dataset	uspto-grants-2012_07
ORD ID	ord-49f20ef0695b4d859e24c327d2c80864
Source note	uspto-grants-2012_07