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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1514527Generated: November 3, 2026

2-(Trifluoromethyl)thiophene → 5-Bromo-2-chloro-1-(5-trifluoromethyl-2-thienylmethyl)benzene

https://huagongshe.com/reaction/1514527

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Trifluoromethyl)thiopheneHCID 2760785—
Reactant5-Bromo-2-chlorobenzaldehydeHCID 10608925—
Product5-Bromo-2-chloro-1-(5-trifluoromethyl-2-thienylmethyl)benzeneHCID 66608635—

Reaction Steps

2-Trifluoromethylthiophene (see Japanese Unexamined Patent Publication No. 2000-34239) and 5-bromo-2-chlorobenzaldehyde obtained in Reference Example 16-(1) were treated in a manner similar to Reference Example 7 to give the target compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08222219B2
Source datasetuspto-grants-2012_07
ORD IDord-2c67c57e8fc64cb89d7cebdca2edb29c
Source noteuspto-grants-2012_07