Sodium Hydroxide → HCID 66670176, compound

Participants

Reaction Steps

A 15.91 g portion of ethyl 5-tert-butyl-1-[2-(4-fluorophenyl)ethyl]-2-methyl-1H-pyrrole-3-carboxylate was dissolved in a mixture of 200 ml of ethanol and 20 ml of tetrahydrofuran at 80° C., and 96.01 ml of a 5 M sodium hydroxide aqueous solution was added thereto, followed by overnight stirring at the same temperature and then further stirring at 100° C. for 6 hours. The reaction liquid was concentrated to about 150 ml, and, under ice-cooling, 6 M hydrochloric acid was added thereto until pH became 1. The resulting solid was collected by filtration and washed with water to obtain 14.04 g of 5-tert-butyl-1-[2-(4-fluorophenyl)ethyl]-2-methyl-1H-pyrrole-3-carboxylic acid as a light brown solid.

Provenance & Evidence