HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenethyl Alcohol → 1-[2-(4-fluorophenyl)ethyl]-2-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenethyl Alcohol | HCID 82068 | — |
| Reactant | 2-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile | HCID 15314672 | — |
| Reactant | Cyanomethylenetrimethylphospholan | HCID 66670364 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-[2-(4-fluorophenyl)ethyl]-2-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile | HCID 57570232 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A 266 mg portion of 2-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile was dissolved in 10 ml of toluene, and 0.382 ml of 2-(4-fluorophenyl)ethanol and 352 mg of cyanomethylenetrimethylphospholan were added, followed by stirring at 100° C. for 1.5 hours. The reaction liquid was concentrated under a reduced pressure, and the resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:9-1:4) to obtain 451 mg of 1-[2-(4-fluorophenyl)ethyl]-2-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222274B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-e3155ce5c0ce425197359780e322346d |
| Source note | uspto-grants-2012_07 |