HCID 66670153, compound → HCID 66670292, compound

Participants

Reaction Steps

A 501 mg portion of benzyl 5-[3-(dimethylamino)propyl]-1-[2-(4-fluorophenyl)ethyl]-2-methyl-1H-pyrrole-3-carboxylate was dissolved in a mixed solvent of 1 ml ethanol and 5 ml tetrahydrofuran, and 119 mg of 10% palladium-activated carbon was added, followed by stirring at room temperature for 15 hours under an atmosphere of hydrogen. The reaction liquid was filtered through celite, and the filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (methanol:chloroform=10:90-15:85-20:80), to obtain 342 mg of 5-[3-(dimethylamino)propyl]-1-[2-(4-fluorophenyl)ethyl]-2-methyl-1H-pyrrole-3-carboxylic acid as a colorless solid.

Provenance & Evidence