Ammonium Acetate → HCID 66670204, compound

Participants

Reaction Conditions

Reaction Steps

A 6.00 g portion of benzyl 2-acetyl-4-oxo-4-phenylbutanoate was dissolved in a mixture of 54 ml acetic acid and 5.4 ml water, and 14.9 g of ammonium acetate was added, followed by stirring at 100° C. for 1 hour. After evaporation of the solvent under a reduced pressure and subsequent addition of ethyl acetate-water, the ethyl acetate layer was washed with a 1 M sodium hydroxide aqueous solution and saturated brine, followed by drying with anhydrous sodium sulfate. Then, the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:5-1:4) to obtain 3.84 g of benzyl 2-methyl-5-phenyl-1H-pyrrole-3-carboxylate as a light purple solid.

Provenance & Evidence