Flupirtine → Flupirtine maleate

Participants

Reaction Conditions

Reaction Steps

30 g of Flupirtine base were dissolved in 1080 ml of isopropanol at 50° C. 12.8 g of Maleic acid was dissolved in 96 ml of isopropanol at 20° C. Flupirtine solution was cooled down to 20° C. Maleic acid solution was added to Flupirtine solution in the course of stirring. The sediment was formed almost at once. The mixture was heated and stirred for 60 min at 60° C. Then the mixture was cooled down to 20° C. The sediment was filtered and washed three times with cooled (0° C.) Isopropanol. The sediment formed was white. 41.4 g of the product was formed.

Provenance & Evidence