Hydrochloric Acid → HCID 66718168, compound

Participants

Reaction Steps

6-[3-(3,4-Difluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (1.00 g, 2.66 mmol) in THF (6.25 mL), methanol (1.75 mL), and water (6.25 mL) was treated with lithium hydroxide (130 mg, 5.31 mmol) overnight at room temperature. Addition of aqueous hydrochloride solution (1 N, 100 mL) and extraction with ethyl acetate afforded the title compound (850 mg, 88%) as a white solid. MS: m/e=361.1 [M−H]−.

Provenance & Evidence