Tert-Butylamine → HCID 46929064, compound

Participants

Reaction Conditions

Reaction Steps

A trimethylaluminium solution (2 M in toluene, 798 μL, 1.6 mmol) in dioxane (7.5 mL) was added to tert-butylamine (174 μL, 1.6 mmol) and the mixture was stirred for 1 h at 50° C. 6-[3-(3,4-Difluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (150 mg, 0.4 mmol) in dioxane (7.5 mL) was added and stirring was continued overnight at 85° C. Chromatography (silica, ethyl acetate: heptane=1:4 to 1:1) afforded the title compound (20 mg, 13%) as a colourless solid. MS: m/e=416.4 [M−H]−.

Provenance & Evidence