3-Amino-3-methyloxetane → HCID 46929236, compound

HRID 1514736Notes

Reaction equation

HRID 1514736 reaction equation
[CH2:1]([C:5]1[C:9]([CH2:10][O:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=O)=[CH:14][N:13]=2)=[C:8]([CH2:21][OH:22])[O:7][N:6]=1)[CH2:2][CH2:3][CH3:4].[CH3:23][C:24]1([NH2:28])[CH2:27][O:26][CH2:25]1>>[CH2:1]([C:5]1[C:9]([CH2:10][O:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([NH:28][C:24]3([CH3:23])[CH2:27][O:26][CH2:25]3)=[O:18])=[CH:14][N:13]=2)=[C:8]([CH2:21][OH:22])[O:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 66718228HCID 66718228, compound

Product 1

HCID 46929236HCID 46929236, compoundYield 48%

Procedure

As described in example 52g, 6-[3-butyl-5-hydroxymethyl-isoxazol-4-ylmethoxy]-nicotinic acid (49 mg, 0.16 mmol) was converted, using 3-methyl 3-oxetanamine instead of cyclobutylamine, to the title compound (29 mg, 48%) which was obtained as a colorless oil. MS: m/e=376.3 [M+H]+.

Sources & evidence

ORD record
ord-79283aa8ff0a4e278a9607dbef0160e3
Source dataset
uspto-grants-2012_07
Patent number
US08222246B2

Reaction notes

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