Sodium Hydroxide → HCID 66718228, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-[3-butyl-5-hydroxymethyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (490 mg, 1.53 mmol) in dioxane (20 mL) was added aqueous sodium hydroxide (2 M, 10 mL) and the reaction mixture was stirred at 90° C. for 17 h. The mixture was concentrated and the residue was acidified with aqueous hydrochloric acid (2 M, 15 mL) and extracted twice with ethyl acetate. The combined organic phases were washed with brine, dried over sodium sulfate and concentrated to a yellow oil to afford the title compound (480 mg, 100%). MS: m/e=305.4 [M−H]−.

Provenance & Evidence