Phenyl chloroformate → HCID 58097294, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of aminopyrazole of Example 2 (325 g, 0.707 moles) in ethyl acetate (1625 ml) under nitrogen, was added sodium bicarbonate aqueous solution (8% w/v, 1625 ml, 1.54 moles). Phenyl chloroformate (145 ml, 1.155 moles) was added over 15 minutes and stirred at 20° C. for 16 hours. The organic phase was separated and washed with water (1625 ml). Solvent was distilled under reduced pressure and replaced by n-heptane (1625 ml). The solution was cooled to 5° C. and granulated for 3 hours. The solid was collected by filtration to give the title compound as a white solid (368 g, 88%).

Provenance & Evidence