참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | 4-chloro-N-(3,4-dimethyl-phenyl)-3-nitro-benzenesulfonamide | HCID 4795498 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-amino-N-(3,4-dimethyl-phenyl)-3-nitro-benzenesulfonamide | HCID 66966116 | — |
반응 단계
To a suspension of 4-chloro-N-(3,4-dimethyl-phenyl)-3-nitro-benzenesulfonamide (0.22 g) in dioxane (2 mL) was added NH4OH (3 mL). The reaction mixture was heated to 95° C. for 8 h. The mixture was cooled to room temperature, diluted with water, and extracted with CH2Cl2. The extract was dried over Na2SO4 and concentrated in vacuo. Purification by column chromatography (SiO2, 3:1 hexane/EtOAc) afforded 4-amino-N-(3,4-dimethyl-phenyl)-3-nitro-benzenesulfonamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08222248B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_07 |
|---|
| ORD ID | ord-b777f18b188341a190f700d440237782 |
|---|
| 출처 메모 | uspto-grants-2012_07 |
|---|
