HCID 66965934, compound → HCID 66966145, compound

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A solution of {4-[6-(3-Chloro-phenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethyl-phenoxy}-acetic acid ethyl ester (71.7 mg) in 2N LiOH aqueous solution (1 mL) and THF (1 mL) was stirred at room temperature for 16 h. The mixture was washed with Et2O. The aqueous layer was acidified to pH 3 with 1N HCl aqueous solution, extracted with EtOAc, and the organic extracts were dried over Na2SO4, filtered and concentrated under reduced pressure to give {4-[6-(3-Chloro-phenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethyl-phenoxy}-acetic acid as white solid: MS (m/z) 444 (M+1); 1H NMR (MeOD, 400 MHz) δ 8.17 (s, 1H), 7.84 (d, 1H), 7.82 (s, 1H), 7.62 (d, 1H), 7.54 (d, 1H), 7.25 (t, 1H), 7.06 (dd, 1H), 6.70 (s, 2H), 4.59 (s, 2H), 2.06 (s, 6H).

Provenance & Evidence