反应详情

A mixture of 4-hydroxy-2,6-dimethyl-benzaldehyde (150 mg), chloroacetonitrile (0.1 mL), and Cs2CO3 (390 mg) in acetone (10 mL) was stirred at room temperature for 16 h. The mixture was concentrated, diluted with water, and extracted with EtOAc. The organic extracts were washed with brine, dried over Na2SO4, and concentrated in vacuo. Purification by column chromatography (SiO2, 3:1 hexane/EtOAc) gave (4-formyl-3,5-dimethyl-phenoxy)-acetonitrile.

1. concentrationThe mixture was concentrated
2. additiondiluted with water
3. extractionextracted with EtOAc
4. washThe organic extracts were washed with brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo
7. customPurification by column chromatography (SiO2, 3:1 hexane/EtOAc)