Water → HCID 66965832, compound

Participants

Reaction Steps

To a stirred suspension of 2-(2,6-dimethylphenyl)-3H-benzoimidazole-5-carbonyl chloride HCl salt (160 mg) and naphthalen-2-ylamine (72 mg) was added DIPEA (0.27 mL). The resulting solution was stirred for at room temperature for 18 h then the mixture was partioned between water and EtOAc. The aqueous layer was extracted with EtOAc. The combined organic layers were dried, filtered and concentrated. The residue was purified by an amino column using hexanes/ethyl acetate (1:4) as eluent and gave 2-(2,6-dimethylphenyl)-3H-benzoimidazole-5-carboxylic acid naphthalen-2-ylamide as a white solid; MS (ESI)m/z 392 (M+H).

Provenance & Evidence