Water → HCID 87217684, compound

Participants

Reaction Steps

To a stirred suspension of 2-(2,6-dimethylphenyl)-3H-benzoimidazole-5-carbonyl chloride HCl salt (from Example 1-247) (160 mg) and 7-amino-4-methyl-chromen-2-one (87 mg) was added DIPEA (0.27 mL). The resulting solution was stirred at room temperature for 18 h. The mixture was partioned between water and EtOAc and the aqueous layer was extracted with EtOAc. The combined organic layers were dried, filtered and concentrated. The residue was purified by an amino column using hexanes/ethyl acetate (1:4) and gave 2-(2,6-dimethylphenyl)-3H-benzoimidazole-5-carboxylic acid (4-methyl-2-oxo-2H-chromen-7-yl)-amide as a white solid; MS (ESI)m/z 424 (M+H).

Provenance & Evidence