HCID 66965897, compound → HCID 66966120, compound

Participants

Reaction Steps

To a solution of N-(3,4-dimethyl-phenyl)-3-(2-hydroxyethylamino)-4-nitro-benzamide (70 mg) in MeOH (20 mL) was added 10% Pd/C (10 mg). The reaction mixture was stirred under H2 balloon at room temperature for 16 h. The reaction mixture was filtered through celite, washed with MeOH. The filtrate was concentrated under reduced pressure to give 4-amino-N-(3,4-dimethyl-phenyl)-3-(2-hydroxy-ethylamino)-benzamide as a grey solid; MS (m/z) 300 (M+1); 1H NMR (DMSO-d6, 400 MHz) δ 9.54 (s, 1H), 7.51 (s, 1H), 7.45 (d, 1H), 7.18 (d, 1H), 7.04 (d, 2H), 6.57 (d, 1H), 5.12 (s, 2H), 4.69 (t, 1H), 4.50 (t, 1H), 3.65 (q, 2H), 3.19 (q, 2H), 2.20 (s, 3H), 2.17 (s, 3H).

Provenance & Evidence