HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1514923Generated: November 4, 2026
Methyl 4-aminobenzoate → Methyl 4-amino-3-iodobenzoate
https://huagongshe.com/reaction/1514923
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 4-aminobenzoate | HCID 12082 | — |
| Reactant | Trimethylbenzylammonium Dichloroiodate | HCID 56924451 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 4-amino-3-iodobenzoate | HCID 4104649 | — |
Reaction Steps
To a solution of 4-amino-benzoic acid methyl ester (1 g) in 10 mL of acetic acid and 10 mL of CH2Cl2 was added benzyltrimethylammonium dichloroiodate (2.763 g) at ambient temperature. The reaction mixture was heated at 55° C. for 1.5 h. The reaction mixture was concentrated to give the crude 4-amino-3-iodo-benzoic acid methyl ester: MS (m/z) 278.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08222248B2 |
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| Source dataset | uspto-grants-2012_07 |
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| ORD ID | ord-e4de02b1bf7f4dcd936375031b15449f |
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| Source note | uspto-grants-2012_07 |
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