反应详情

温度

60 °C

To a solution of the crude 4-amino-3-iodo-benzoic acid methyl ester in 20 mL of acetic acid was added acetic anhydride (1.25 mL). The reaction was heated at 60° C. for 1 h. The reaction mixture was quenched with water, extracted with ethyl acetate, dried over Na2SO4, and concentrated in vacuo. Purification by flash chromatography (SiO2, 1:3 EtOAc/Hexane) afforded 4-acetylamino-3-iodo-benzoic acid methyl ester: MS (m/z) 320.0 (M+1).

1. customThe reaction mixture was quenched with water
2. extractionextracted with ethyl acetate
3. dry with materialdried over Na2SO4
4. concentrationconcentrated in vacuo
5. customPurification by flash chromatography (SiO2, 1:3 EtOAc/Hexane)