HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1514930Generated: October 25, 2026
Triphenylphosphine → methyl 2-(2,6-dimethylphenyl)-1H-indole-6-carboxylate
https://huagongshe.com/reaction/1514930
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Methyl 4-(2,6-dimethylphenylethynyl)-3-(2,2,2-trifluoroacetylamino)-benzoate | HCID 86651266 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | methyl 2-(2,6-dimethylphenyl)-1H-indole-6-carboxylate | HCID 66966102 | — |
Reaction Steps
A mixture of methyl 4-(2,6-dimethylphenylethynyl)-3-(2,2,2-trifluoroacetylamino)-benzoate (103 mg, 270 μmol), copper (I) iodide (2 mg, 10 μmol), triphenylphosphine (6 mg, 23 μmol), and K3PO4 (117 mg, 550 μmol) in dioxane (2 mL) was heated at 115° C. in a microwave apparatus for 15 min. The solution was concentrated, then chromatographed using a gradient of 0-40% heptane/ethyl acetate to afford methyl 2-(2,6-dimethylphenyl)-1H-indole-6-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08222248B2 |
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| Source dataset | uspto-grants-2012_07 |
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| ORD ID | ord-be20f2bccbf9495ba20d5cf6beefd489 |
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| Source note | uspto-grants-2012_07 |
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